Anticholinergic agents:
Sweat is activated by post-ganglionic sympathetic fibres which behave like parasympathetic or cholinergic fibres.
Solifenacin Succinate (vesicare)
Oxybutynin Hydrochloride (Ditropan)
Glycopyrollate (Robinul, Avert) |
5 mg bid prn
5 mg tid prn
1 à 2 mg tid prn |
Draw backs of anticholinergics:
Unfortunately, the anti-cholinergic effects generated by these medications are worse than the sweating itself: tachycardia, dry mouth, sluggishness of the intestinal motility, worsening of certain conditions like: glaucoma, toxic erythema, convulsions etc... Moreover, these symptoms appear long before the sweat is under control. It follows that anticholinergics have little place in the management of HH.
There are reports in the literature where cases have responded to the following medications:
Indomethacine (indocid)
Diltiazem (cardizem)
Clonidine (Catapres)
Propranolol (Inderal)
Oxprenolol (Trasicor) |
25 mg tid
30 to 60 mg tid
0.1 mg BID
20 mg TID
20 mg TID |
Topical treatment of HH >>
